Coenzyme Q10 (CoQ10/Ubiquinol)

CoQ10 is an antioxidant synthesized by the body that declines with age and is depleted by statin medications. The CoQ10-statin connection is clinically important: statins reduce CoQ10 synthesis by up to 40%, and this correlates with the statin side effect of muscle pain (myalgia) in approximately 5-10% of users. For statin users over 50, CoQ10 supplementation has strong clinical rationale. The broader longevity evidence shows CoQ10 improves mitochondrial function and reduces oxidative stress markers. The ubiquinol form (reduced CoQ10) absorbs 3-8x better than ubiquinone in older adults. Dose: 100-200mg ubiquinol daily with fat-containing meal. Standard warning: the effect size in healthy, non-statin-using younger adults is modest.