Lithium Orotate (Low-Dose)

Low-dose lithium is the most surprising and most evidence-backed supplement that almost nobody takes. This is not prescription psychiatric lithium (which is dosed at 600-1200mg): lithium orotate provides 5-10mg elemental lithium, which is close to the amount found in mineral-rich drinking water in regions with exceptionally low rates of neurodegenerative disease. Epidemiological studies in Texas, Japan, and Austria find inverse correlations between lithium in drinking water and rates of dementia, suicide, and violent crime — with the strongest signal for Alzheimer's prevention. A 2020 double-blind RCT in mild cognitive impairment patients found 300mcg lithium daily stabilized cognitive function over 15 months versus decline in placebo group. The mechanism involves inhibition of GSK-3β, a protein involved in tau phosphorylation and neurodegeneration. At low doses, side effect profile is minimal. This is a research-stage recommendation — discuss with a physician.