Approximately 42% of American adults are vitamin D deficient (serum 25-OH-D below 20 ng/mL), and deficiency correlates with 35+ disease states including cardiovascular disease, autoimmune conditions, and all-cause mortality. The evidence for supplementation in deficient individuals is strong: a 2022 VITAL trial of 25,000 participants found 2,000 IU/day D3 reduced cancer mortality by 25%. The K2 pairing matters: D3 increases calcium absorption, but without K2 (specifically MK-7 form), that calcium may deposit in arteries rather than bones. The combined D3+K2 approach is now standard in longevity medicine. Dose: 2,000-5,000 IU D3 + 100-200 mcg MK-7 K2 daily. Get baseline bloodwork first — optimal level is 40-60 ng/mL, not just above deficiency threshold.
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