Extra virgin olive oil (EVOO) is the most studied component of the Mediterranean diet, and the evidence for its anti-inflammatory effects is exceptional. The PREDIMED trial — a landmark RCT involving 7,447 adults over 5 years — found the Mediterranean diet supplemented with EVOO reduced cardiovascular events by 31% vs a low-fat diet. Oleocanthal, a phenolic compound in fresh EVOO, inhibits COX-1 and COX-2 enzymes with a mechanism identical to ibuprofen at equivalent doses. The catch: most commercially available olive oil labeled extra virgin does not meet EVOO standards — UC Davis testing found 69% of California supermarket olive oils failed EVOO chemical tests. What to look for: harvest date within 12 months on the label, dark glass bottle, California Olive Oil Council certification, or reputable Italian/Greek DOP certification.

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