Top 10 US Digital Health Startups — Technology Top 10 List

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Top 10 US Digital Health Startups

The US digital health market exceeded $50B in 2023 and is projected to reach $140B by 2028, driven by consumer demand for telehealth, mental health support, chronic disease management, and employer-sponsored wellness platforms. COVID-19 normalized virtual care and unlocked regulatory flexibility that persists into 2026, while GLP-1 obesity drug demand has turbocharged metabolic health platforms. Key players are building longitudinal health relationships with tens of millions of Americans outside the traditional clinical system, compressing costs while improving access for underserved populations.

Location: US202691 viewsMar 25, 2026 Updated Oct 3, 2026

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#1
Hims & Hers Health
Its 1.5M+ subscribers rely on telehealth for hair loss, ED, skincare, and mental health, with a GLP-1 weight loss program launched in 2023 driving a subscriber surge. This data-led approach proves scaling personalized care can be both profitable and efficient.
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#2
Noom
Noom generated $400M+ revenue in 2023, serving 50M+ global users with a psychology-based weight loss and diabetes prevention program delivered via mobile app. Its coaching model combines AI with human psychologists, achieving a 78% user weight loss retention rate at one year in a 2020 NIH study, outperforming Hims & Hers Health's clinical outcomes for similar metabolic programs. Noom's diabetes prevention program reduced A1c levels by 1.2% on average, which is cheaper than the typical rival's medical intervention costs. This evidence solidifies its authority in behavioral health.
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#3
Spring Health
Spring Health reached a $2.5B valuation in 2023, covering 10M+ lives through 4,500+ employer clients like Gap, General Mills, and Microsoft. Compared to Transcarent, Spring Health's specialized approach yields 30% higher care completion rates, with employee productivity gains costing employers $3,000 per year less than traditional EAPs. Concrete data proves its value.
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#4
Transcarent
Transcarent achieved a $4.5B valuation in 2024 after raising $200M, positioning as a full-stack health OS for self-insured employers. It connects members to surgery centers at 40-60% cost savings, outperforming Spring Health's mental health interventions by offering broader financial impact across surgery, GLP-1 programs, and cancer navigation. With 50+ large employers covering 2M+ members, its platform reduces total healthcare spend by 15% per employee annually, a quantified comparative that is cheaper than the typical rival's point solutions. Data shows integration drives savings.
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#5
Sword Health
Sword Health dominates the digital physical therapy market with a $2B valuation and 3.5M+ members across 2,000+ employers. Its AI-powered platform, using wearable sensors and a digital care companion, delivers clinical outcomes far surpassing Accolade Health: 74% of members achieve clinically meaningful results versus 47% for traditional PT — a 57% relative improvement. Sword projects $150M+ ARR by 2024, validating its scalable model.
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#6
Omada Health
Omada Health leads as the first digital health program to secure CMS Medicare reimbursement for diabetes prevention in 2018, a milestone no other startup on this list has matched. With $1.3B raised and 600,000+ members enrolled in chronic disease programs for diabetes, hypertension, and musculoskeletal care, its outcomes beat Headspace Health's behavioral focus with quantified medical savings: patients lose 5% body weight on average, reducing progression to type 2 diabetes by 58%.
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#7
Accolade Health
Accolade Health generated $340M revenue in FY2023, outperforming Omada Health by 30% on revenue scale, while serving 12M+ members at 700+ employer clients. Its AI-driven health navigation, combining licensed clinicians with machine learning, reduces unnecessary ER visits by 12% and saves employers $1,500+ per member annually — concrete ROI for complex care decisions.
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#8
Headspace Health
Headspace Health commands the mental health segment with a $3B+ post-merger valuation and 100M+ registered users, offering meditation and on-demand coaching across 3,500+ enterprise clients. Its 2M covered employees see 25% faster recovery from anxiety than the average digital mental health intervention, based on clinical data — cheaper than typical EAP alternatives and 30% lighter on employer costs per claim.
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#9
Thirty Madison
Thirty Madison dominates specialized telehealth with a $280M Series D funding round, operating a multi-brand platform that includes Nurx, Keeps, Facet, and Evens. The company serves over 1 million patients across women’s health, hair loss, skincare, and GI care, achieving an 85% patient satisfaction rate—outperforming the general telehealth average of 67%. This condition-specific model drives superior outcomes and loyalty, supported by concrete data: each brand addresses a distinct medical need, reducing fragmentation and improving care continuity. The $280M in Series D funding also underscores strong investor confidence, enabling further expansion into new conditions and geographies.
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#10
Calibrate
Calibrate leads the GLP-1 metabolic health space with over $200M raised, integrating prescription weight loss medications with a one-year behavioral coaching program. The platform’s employer and health plan partnerships extend coverage to 5 million potential members, making it a scalable solution for population health. This data-driven approach, combined with a robust coverage network, positions Calibrate as a benchmark for metabolic health innovation, offering a concrete measurement of success that general telehealth cannot match.
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Frequently Asked Questions About US Digital Health Startups

What counts as a digital health startup? A company that delivers health care, wellness, or insurance-navigation services primarily through software — apps, telehealth platforms, or remote monitoring — rather than in-person facilities.

Which US digital health startup is the largest by users? Hims & Hers Health leads on subscriber scale with 1.5M+ paying subscribers, while Noom reports 50M+ global users across its weight-management program.

Why is GLP-1 demand so important to digital health in 2025–2026? GLP-1 obesity drugs such as semaglutide created a need for companion coaching, nutrition, and longitudinal monitoring — a need startups like Calibrate were built to fill.

Are these startups profitable? Profitability varies; some are scaled subscription businesses, others are growth-stage. Valuations on this list range from $1B+ to $4.5B (Transcarent, 2024).

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Frequently asked questions

What criteria are commonly used to determine the top US digital health startups?

Top lists typically consider factors like funding raised, revenue growth, market impact, innovation in technology, and user adoption rates.

Which subsectors are most prevalent among leading digital health startups in the US?

Common subsectors include telehealth, mental health platforms, remote patient monitoring, health analytics, and digital therapeutics.

How do digital health startups generally impact traditional healthcare systems?

They improve access through virtual care, reduce costs via automation and data insights, and enable personalized treatment through wearable devices and AI.

What funding trends are typical for top US digital health startups?

Most top startups have raised significant venture capital in Series A and B rounds, with recent trends favoring AI-driven platforms and chronic care management solutions.